Program outline | Speakers
PROGRAM OUTLINE
(subject to minor modifications)
Wednesday, June 11
| 8:00 - 13:30 |
Registration |
| Educational Course |
Nanoparticles in medicine: particle design, inhalation administration, therapeutic approaches |
| 9:00 - 9:15 |
Introduction to the course
Michael Bur, Saarland University, Germany
|
| 9:15 - 10:15 |
Inhalation of nanoparticles: physical aspects
Wolfgang Koch, Fraunhofer ITEM, Germany
|
| 10:15 - 11:15 |
Material and formulation considerations for pulmonary administration of therapeutic nanoparticles
Erik Rytting, University of Marburg, Germany |
| 11:15 - 12:15 |
Pulmonary cell culture models to study safety and efficacy of therapeutic aerosols
Michael Bur, Saarland University, Germany |
| 12:15 - 12:30 |
Discussion and open questions
Michael Bur, Saarland University, Germany |
|
| 12:30 - 13:30 |
Registration / poster mounting |
|
| 13:30 - 13:40 |
Opening address to the 11th International Inhalation Symposium
Uwe Heinrich, Symposium President, Fraunhofer ITEM, Germany |
|
| Plenary Session I |
Standardization, physico-chemical characteristics, and cell-particle interactions
Chairpersons: David Mark, Health and Safety Laboratory, UK; Jan Knebel, Fraunhofer ITEM, Germany |
| 13:40 - 13:45 |
Chairman's introduction to the session |
| 13:45 - 14:15 |
European and international standardization progress in the field of engineered nanoparticles
Gérard Rivière, European Committee for Standardization and Research (CEN-STAR), Belgium |
| 14:15 - 14:45 |
Physico-chemical characterization of nanoparticles in the light of toxicological effects
Volkmar Richter, Fraunhofer IKTS, Germany |
| 14:45 - 15:05 |
Laser-generated pure nanoparticulate reference material
Stephan Barcikowski, Laser Zentrum Hannover e. V., Germany |
| 15:05 - 15:25 |
Dissolution behavior of a nanoparticle in a nanoscale volume of solvent: thermodynamic and kinetic considerations
Wolfram Vogelsberger, Friedrich Schiller University Jena, Germany |
| 15:25 - 15:45 |
Characterization of nanoparticle size and state prior to nanotoxicological studies
Patrick Hole, NanoSight Ltd., UK |
| 15:45 - 16:05 |
Engineered nanoparticles induce a pulmonary surfactant dysfunction after surface area cycling in vitro
Carsten Schleh, Fraunhofer ITEM, Germany |
|
| 16:05 - 16:35 |
Break |
|
| 16:35 - 17:05 |
Endocytic pathways: gateways for the cellular internalization of nanoparticles
Arwyn T. Jones, Cardiff University, UK |
| 17:05 - 18:05 |
Nanoparticle-bio-interactions: controlled design and cellular response
Lutz Mädler, University of Bremen, Germany, and Andre Nel, UCLA Medical Center, USA (combined presentation) |
| 18:05 - 18:35 |
Towards a structure/activity relationship for nanoparticle toxicity
Ken Donaldson, University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, UK |
| Plenary Session II |
Potential sources of human exposure, pulmonary delivery, and lung deposition evaluation
Chairpersons: Hillel Koren, United States Environmental Protection Agency, USA; Wolfgang Koch, Fraunhofer ITEM, Germany |
| 9:00 - 9:05 |
Chairman's introduction to the session
|
| 9:05 - 9:35 |
Facing the key workplace challenge: assessing and preventing exposure to nanoparticles
Kaarle Hämeri, Finnish Institute of Occupational Health and University of Helsinki, Finland
|
| 9:35 - 10:05 |
Problems and experience of measuring worker exposure to manufactured nanoparticles
David Mark, Health and Safety Laboratory, UK |
| 10:05 - 10:35 |
Workplace exposure characterization at a TiO2 nanoparticle production site
Markus Berges, BGIA – BG Institute for Occupational Health and Safety, Germany |
|
| 10:35 - 11:05 |
Break |
|
| 11:05 - 11:25 |
Nanoparticle release from powders - physico-chemical characteristics and standardization
Michael Stintz, Technical University of Dresden, Germany |
| 11:25 - 11:45 |
Charge-based personal aerosol samplers
Martin Fierz, University of Applied Sciences Northwestern Switzerland, Switzerland |
| 11:45 - 12:15 |
Extended applications of an on-line lung-deposited nanoparticle surface area monitor
Heinz Fissan, University of Duisburg-Essen, Germany |
|
| 12:15 - 13:15 |
Lunch |
|
| 13:15 - 14:35 |
General Poster Session |
|
| Plenary Session III |
Pulmonary and systemic toxicity
Chairpersons: Günter Oberdörster, University of Rochester, USA; Otto Creutzenberg, Fraunhofer ITEM, Germany |
| 14:35 - 14:40 |
Chairman's introduction to the session |
| 14:40 - 15:10 |
Local and vascular health effects associated with the pulmonary deposition of engineered-manufactured nanomaterials: research challenges and preliminary findings
Kevin Dreher, United States Environmental Protection Agency, USA |
| 15:10 - 15:30 |
Extrapulmonary effects of inhaled ultrafine carbon particles in mice
Tobias Stöger, Helmholtz Zentrum München, Germany |
| 15:30 - 15:50 |
Thrombogenic effects of nano-sized carbon particles in vivo
Fritz Krombach, Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University Munich, Germany |
| 15:50 - 16:20 |
The in vitro interaction of lung epithelial cells and microvasculature endothelial cells with metal oxide nanoparticles
Ian M. Kennedy, University of California Davis, USA |
|
| 16:20 - 16:50 |
Break |
|
| 16:50 - 17:20 |
Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells
Julie Muller, Solvay S. A. and Catholic University of Louvain, Unit of Industrial Toxicology, Belgium |
| 17:20 - 17:40 |
In vitro immunomodulatory effects of metallic, uncoated, monodispersed nanoparticles in the low nanometer range
Gertie Janneke Oostingh, University of Salzburg, Austria |
| 17:40 - 18:00 |
Mechanisms of nano-sized carbon particle induced cardiovascular impairments in spontaneously hypertensive rats
Swapna Upadhyay, Helmholtz Zentrum München, Germany |
| Plenary Session IV |
Use in therapy and diagnosis
Chairpersons: Andre Nel, UCLA Medical Center, USA; Jens Hohlfeld, Fraunhofer ITEM, Germany |
| 9:00 - 9:05 |
Chairman's introduction to the session
|
| 9:05 - 9:35 |
Respiratory nanomedicines – opportunities for improving drug delivery across the air-blood barrier
Claus-Michael Lehr, Saarland University, Germany
|
| 9:35 - 10:05 |
Controlled release formulations for pulmonary drug delivery: Utilization of nanosuspensions and nanostructured dry powders
Régis Cartier, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany |
| 10:05 - 10:25 |
Nanoparticle-induced cell culture models for protein aggregation diseases
Anna von Mikecz, IUF at the Heinrich Heine University Düsseldorf, Germany |
|
| 10:25 - 11:45 |
General Poster Session / Coffee |
|
| 11:45 - 13:00 |
Lunch |
|
| 13:00 - 15:00 |
Sightseeing program - two alternatives:
a) Boat ride around the lake Maschsee
b) Hannover Townhall including a visit to the panorama platform |
|
| 15:00 - 15:30 |
The design of novel poly(vinyl alcohol) fluorescently labeled nanoparticles suitable for drug delivery and inhalation toxicokinetics
Stuart Jones, King’s College London, UK |
| 15:30 - 16:00 |
Advances in pulmonary nanotherapeutics
Justin S. Hanes, The John Hopkins University Baltimore, The Institute for NanoBioTechnology (INBT), USA |
|
| 16:00 - 16:10 |
Awarding of prizes for the best two posters presented |
|
| 16:10 - 16:35 |
Break |
|
| Plenary Session V |
Mechanisms of toxicity and hazard evaluation
Chairpersons: Kevin Dreher, United States Environmental Protection Agency, USA; Uwe Heinrich, Fraunhofer ITEM, Germany |
| 16:35 - 16:40 |
Chairman's introduction to the session |
| 16:40 - 17:10 |
Comparative pulmonary response to inhaled nanostructures: considerations on test design and endpoints
Jürgen Pauluhn, Bayer HealthCare AG, Germany |
| 17:10 - 17:40 |
Screening assays for predicting nanoparticle toxicity
Günter Oberdörster, University of Rochester, USA |
|
| 19:00 |
Dinner reception for all participants of the symposium at the Hotel Courtyard by Marriott Hannover Maschsee |
Plenary Session V
(continued) |
Mechanisms of toxicity and hazard evaluation
Chairpersons: Kevin Dreher, United States Environmental Protection Agency, USA; Uwe Heinrich, Fraunhofer ITEM, Germany |
| 9:00 - 9:30 |
Role of nanoparticle surface reactivity on pulmonary hazard effects and development of a base set of toxicity assays as a component of nanoparticle risk management
David Warheit, DuPont Haskell Global Centers for Health and Environmental Sciences, USA
|
| 9:30 - 10:00 |
Engineered nanoparticle respiratory exposure and potential risk for cardiovascular toxicity
Petia Simeonova, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, USA
|
| 10:00 - 10:30 |
Recognition determines toxicity: studies on immune recognition of engineered nanomaterials
Bengt Fadeel, Institute of Environmental Medicine, Karolinska Institute, Sweden |
|
| 10:30 - 11:00 |
Break |
|
| 11:00 - 11:30 |
Nanomaterials - cell interactions: how carbon nanotubes affect cell physiology
Peter Wick, EMPA, Swiss Federal Laboratories for Materials Testing and Research, Switzerland |
| 11:30 - 11:50 |
Translocation of inhaled 20-nm iridium or carbon nanoparticles from the lungs of rats to blood
Wolfgang Kreyling, Helmholtz Zentrum München, Germany |
| 11:50 - 12:10 |
Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance
Lan Ma-Hock, BASF SE, Germany |
| 12:10 - 12:30 |
Carcinogenicity of inhaled nanoparticles
Markus Roller, BMR - Advisory Office for Risk Assessment, Germany |
| 12:30 - 12:40 |
Closing remarks
Uwe Heinrich, Symposium President, Fraunhofer ITEM, Germany |
|
End of Symposium |
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